How Does Generic Avanafil Work?

Generic Avanafil belongs to the group of PDE5 inhibitors. These medications have been successfully used for years in the treatment of erectile dysfunction. Avanafil stands out particularly for its fast onset of action and relatively favorable side effect profile.

Mechanism of action explained

To understand how Avanafil works, it is important to know what happens in the body during an erection:

During sexual stimulation, nitric oxide (NO) is released in the nerves and blood vessels of the penis. This activates an enzyme that causes the production of cGMP (cyclic guanosine monophosphate). cGMP causes the smooth muscles in the blood vessels of the penis to relax, allowing more blood to flow in and an erection to occur.

The enzyme PDE5 breaks down cGMP. In men with erectile dysfunction, this process is often disrupted. Avanafil inhibits PDE5, causing cGMP to remain present longer. The result is better and longer-lasting blood flow to the penis during sexual stimulation.

Why does Avanafil work so fast?

Avanafil has a very high selectivity for the PDE5 enzyme. This means it has much less influence on other enzymes in the body (such as PDE6 in the eye or PDE11 in muscle tissue) than older medications such as Sildenafil or Tadalafil. Because of this high selectivity, the effect occurs faster (often within 15-30 minutes) and certain side effects are less pronounced.

Factors that influence the effect

Dosage: 50 mg works well for many men, but 100 mg is the optimal dosage for most men.
Meal: Unlike Sildenafil, Avanafil can be taken with or without a meal. However, a very heavy meal can slightly delay absorption.
Alcohol: Moderate use usually has little influence. Excessive alcohol use can reduce the effect and increase side effects.
Age and health: Older men or men with certain conditions (such as diabetes or cardiovascular disease) may sometimes need longer before the effect occurs.
Other medications: Some medications (especially nitrates) are absolutely incompatible with PDE5 inhibitors and can cause dangerous blood pressure drops.

How long does it remain effective?

The duration of action of Avanafil averages between 4 and 6 hours. This is comparable to Sildenafil (Viagra). For men who want a longer duration of action, Tadalafil (Cialis) may be a better option (up to 36 hours).

Related articles:
Side Effects of Generic Avanafil • Avanafil vs Viagra and Cialis

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